MPEG-PLA-COOH, MW x 2K, n 2K combines a 2K poly(lactic acid) (PLA) segment with a 2K methoxy polyethylene glycol (MPEG) segment and terminal carboxylic acid functionality. This biodegradable amphiphilic block copolymer specifically supports bioconjugation, nanoparticle development, drug delivery research, and functional biomaterial design.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic PLA with hydrophilic MPEG for amphiphilic polymer design and formulation research.
- PLA MW 2K: The 2K PLA segment specifically provides a compact biodegradable hydrophobic component for polymer assembly and material development.
- MPEG MW 2K: The 2K MPEG segment provides a hydrophilic component that supports amphiphilic polymer behavior and formulation studies.
- Carboxylic Acid Functionality: Terminal COOH specifically provides a reactive site for conjugation with suitable amine-containing molecules.
- EDC/NHS Activation: The carboxyl group specifically supports carbodiimide-mediated activation for coupling with primary amines.
- Stable Amide Formation: Activated carboxyl groups can react with amines to form stable amide linkages.
- Amphiphilic Character: PLA and MPEG provide hydrophobic and hydrophilic regions that support self-assembly in suitable environments.
- Biodegradable Polymer Platform: PLA provides a biodegradable polyester component for delivery systems and functional biomaterial research.
Applications
- Bioconjugation: Terminal COOH supports attachment of amine-containing molecules through established coupling chemistry.
- Ligand Conjugation: Suitable for attaching peptides, proteins, targeting ligands, and other amine-containing research molecules.
- Nanoparticle Research: Supports development and surface functionalization of biodegradable polymeric nanoparticles.
- Polymeric Micelles: Amphiphilic PLA and MPEG blocks support research into self-assembled polymeric structures.
- Drug Delivery Research: Useful for developing functionalized biodegradable polymer-based delivery systems.
- Surface Modification: Terminal carboxyl functionality enables further modification of polymer-containing materials and nanoscale assemblies.
- Polymer Functionalization: Supports EDC/NHS-mediated coupling and development of functional polymer conjugates.
- Biomaterial Research: Useful for designing biodegradable PEG-containing materials with accessible carboxyl functionality.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
MPEG-PLA-COOH, MW x 2K, n 2K combines biodegradable PLA, hydrophilic MPEG, and reactive carboxylic acid functionality, while its balanced block architecture supports bioconjugation, nanoparticles, drug delivery, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.