Acryloyl-PLLA-PEG-Alkyne (ACRL-PLLA-PEG-ALK), MW x 10K, n 5K combines a 10K poly(L-lactide) (PLLA) segment with a 5K PEG segment. Acryloyl and alkyne end groups provide two distinct reactive functionalities specifically for polymer modification, crosslinking, and click chemistry research.
Key Features and Benefits
- Dual Functional Polymer: Combines reactive acryloyl and alkyne groups within a biodegradable PLLA-PEG block copolymer.
- PLLA MW 10K: The 10K PLLA segment provides a biodegradable hydrophobic component for polymer assembly and material development.
- PEG MW 5K: The 5K PEG segment provides a substantial hydrophilic component and flexible polymer spacer.
- Acryloyl Functionality: The acryloyl group specifically supports radical polymerization, crosslinking, and functional material development.
- Alkyne Functionality: Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with compatible azide-containing molecules.
- Click Chemistry: Alkyne functionality specifically supports efficient conjugation through formation of stable triazole linkages.
- Amphiphilic Character: PLLA and PEG specifically provide hydrophobic and hydrophilic regions for self-assembly and formulation research.
- Biodegradable Polymer Platform: PLLA provides a biodegradable polyester component for functional biomaterial and delivery-system research.
Applications
- Click Chemistry: Terminal alkyne supports CuAAC conjugation with azide-functionalized molecules and materials.
- Polymer Crosslinking: Acryloyl functionality supports radical-mediated crosslinking and polymer network formation.
- Bioconjugation: Useful for attaching compatible ligands, peptides, probes, and other functional molecules.
- Hydrogel Research: Acryloyl functionality supports development of crosslinked polymer networks and hydrogel-based materials.
- Nanoparticle Research: Amphiphilic PLLA-PEG architecture supports development and functionalization of polymeric nanoparticles.
- Drug Delivery Research: Useful for designing functionalized biodegradable polymer-based delivery systems.
- Surface Modification: Dual reactive groups provide flexible routes for polymer and material surface functionalization.
- Biomaterial Research: Supports development of biodegradable materials with orthogonal reactive functionalities.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from prolonged light exposure.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to reach room temperature before opening to minimize condensation.
This product combines biodegradable PLLA-PEG with acryloyl and alkyne functionality, while its dual reactive architecture supports click chemistry, crosslinking, nanoparticles, hydrogels, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.