mPEG-PCL-COOH, MW x 10K, n 5K is a carboxyl-functionalized amphiphilic block copolymer composed of methoxy polyethylene glycol (mPEG) and poly(ε-caprolactone) (PCL). This grade combines approximately 10K PCL with 5K mPEG and a terminal carboxyl (COOH) group, providing a PCL-rich architecture for hydrophobic assembly with a reactive site for bioconjugation and surface modification.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic mPEG for polymer assembly and drug delivery.
- PCL MW 10K: Provides a biodegradable hydrophobic block for core formation and incorporation of hydrophobic compounds.
- mPEG MW 5K: Provides a substantial hydrophilic segment for aqueous compatibility and steric stabilization.
- PCL-Rich Architecture: The 2:1 PCL-to-mPEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies while retaining a substantial hydrophilic PEG component.
- Terminal Carboxyl Group: Provides a reactive COOH group specifically for conjugation with amine-containing molecules through commonly used coupling chemistry such as EDC/NHS activation.
- Bioconjugation Capability: Supports attachment of peptides, proteins, targeting ligands, and other amine-containing molecules for functional polymer and drug delivery research.
- Biodegradable Polymer Platform: Combines a degradable PCL block, hydrophilic PEG segment, and reactive carboxyl functionality in one polymer platform.
Applications
- Nanoparticle Formulation: Supports preparation of functional polymeric nanoparticles and other nanoscale delivery systems.
- Micelle Formation: Supports core-shell assemblies with a hydrophobic PCL core and hydrophilic PEG-containing interface.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Surface Functionalization: Enables modification of polymeric nanoparticles and other materials through terminal COOH chemistry.
- Bioconjugation: Supports EDC/NHS-mediated coupling with amine-containing peptides, proteins, ligands, and other molecules.
- Targeted Delivery: Provides a functional handle for attaching targeting ligands to polymer-based delivery systems.
- Biomaterial Research: Supports development of functional PEG-PCL materials for drug delivery and biomaterial applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
mPEG-PCL-COOH, MW x 10K, n 5K combines a PCL-rich amphiphilic architecture with terminal carboxyl functionality. It specifically supports nanoparticle formulation, micelle formation, hydrophobic drug delivery, bioconjugation, surface modification, targeted delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.