Methyltetrazine-propylamine HCl salt
This product is a compact bioorthogonal reagent featuring a methyltetrazine for rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry and a terminal amine provided as a stable hydrochloride salt. Its small size and high solubility make it especially ideal for probe design, bioconjugation, and in vivo labeling applications.
Key Features and Benefits:
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Methyltetrazine Group: Reacts rapidly with strained alkenes such as TCO and BCN.
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Amine (HCl Salt): Stable, water-soluble form that couples efficiently with carboxyls and NHS esters.
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Compact Structure: Minimal steric hindrance for efficient conjugation.
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High Purity: Ensures reproducibility in chemical biology and drug development workflows.
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Bioorthogonal Reactivity: Enables ultrafast labeling in living systems under mild conditions.
Applications:
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Bioorthogonal Labeling: Fast tetrazine–TCO ligation for in vitro and in vivo use.
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Bioconjugation: Attaches to biomolecules through amide coupling and click chemistry.
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Probe Development: Intermediate for fluorescent, radiolabeled, or affinity probes.
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Drug Delivery: Useful in designing PEGylated or multifunctional therapeutic linkers.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Dissolve in aqueous buffers or anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure to maintain tetrazine integrity.
This product combines ultrafast tetrazine reactivity with a stable amine salt handle, making it an especially versatile tool for bioconjugation, probe development, and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
