Methyltetrazine-PEG8-Azide is a versatile, heterobifunctional linker featuring tetrazine for bioorthogonal click chemistry, an azide group for copper-catalyzed or strain-promoted click reactions, and a PEG8 spacer to enhance solubility and flexibility.
Key Features
- Methyltetrazine Group
Enables fast and selective IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Azide Group
Reacts with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted reactions. - PEG8 Spacer
Enhances water solubility, reduces steric hindrance, and provides flexibility for efficient conjugation.
Applications
- Dual Click Chemistry
Supports sequential or orthogonal bioorthogonal conjugation. - Bioconjugation
Ideal for labeling and linking biomolecules such as proteins, peptides, or nucleotides. - Drug Delivery
Facilitates the development of multifunctional and targeted delivery systems. - Material Science
Useful in modifying surfaces, nanoparticles, or hydrogels with dual reactivity.
Short Description
This product is a dual-functional linker with tetrazine for IEDDA reactions and an azide for click chemistry, separated by a PEG8 spacer. Ideal for bioconjugation, imaging, and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
