Methyltetrazine-PEG4-Maleimide
This product is a bifunctional PEG linker containing a methyltetrazine group, a PEG4 spacer, and a maleimide group. It enables rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) and selective thiol coupling, making it an especially versatile tool for dual bioconjugation.
Key Features and Benefits
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Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal click chemistry.
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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PEG4 Spacer: Improves solubility and reduces steric hindrance.
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Dual Reactivity: Combines tetrazine–TCO click and thiol-selective chemistry.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with TCO-modified partners.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal conjugation handles.
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Material Science: Functionalizes polymers and nanoparticles with versatile chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates tetrazine click reactivity with thiol–maleimide conjugation in a PEG4 scaffold, providing a powerful linker for multifunctional bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
