Methyltetrazine-PEG24-amine HCl salt
This product is a heterobifunctional PEG24 linker featuring a methyltetrazine group for rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry and a terminal amine in hydrochloride salt form for amide coupling. The long PEG24 spacer provides excellent hydrophilicity, flexibility, and extended spacing, making it especially ideal for in vivo labeling, drug delivery, and orthogonal bioconjugation strategies.
Key Features and Benefits:
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Methyltetrazine Group: Reacts rapidly with strained alkenes (e.g., TCO, BCN) via IEDDA click chemistry.
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Amine Group (HCl Salt): Stable, water-soluble form that couples efficiently with carboxyls, NHS esters, and electrophiles.
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PEG24 Spacer: Offers long hydrophilic spacing, reduced steric hindrance, and high solubility.
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High Purity: Ensures reproducibility in demanding research and therapeutic workflows.
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Dual Reactivity: Combines tetrazine bioorthogonal chemistry with amine coupling.
Applications:
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Bioorthogonal Labeling: Enables ultrafast in vitro and in vivo labeling with tetrazine–TCO ligation.
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Bioconjugation: Facilitates dual-functional modification of proteins, peptides, and antibodies.
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Drug Delivery: PEGylated linker improves circulation time, stability, and targeting efficiency.
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Surface Functionalization: Functionalizes polymers, nanoparticles, and hydrogels with dual reactivity.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Dissolve in aqueous or anhydrous solvents; avoid prolonged light and heat exposure to preserve tetrazine integrity.
This product combines ultrafast tetrazine reactivity with an amine handle in a long, hydrophilic PEG spacer, making it an especially powerful tool for orthogonal conjugation, bioorthogonal chemistry, and advanced therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
