Methyltetrazine-amido-PEG7-azide
This product is a heterobifunctional PEG7 linker containing a methyltetrazine for rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry and a terminal azide for CuAAC or SPAAC reactions. The PEG7 spacer specifically provides hydrophilicity, flexibility, and medium-length spacing, enabling orthogonal bioconjugation strategies for advanced chemical biology and drug delivery applications.
Key Features and Benefits:
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Methyltetrazine Group: Reacts rapidly with strained alkenes such as TCOs and BCN via IEDDA click chemistry.
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Azide Group: Supports copper-catalyzed (CuAAC) and strain-promoted (SPAAC) click reactions with alkynes.
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PEG7 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
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Dual Reactivity: Enables orthogonal two-step labeling strategies with high efficiency.
Applications:
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Orthogonal Bioconjugation: Combines tetrazine ligation with azide–alkyne click chemistry.
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Chemical Biology: Useful in dual-labeling experiments for probes and imaging agents.
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Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers with dual reactive handles.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain azide and tetrazine stability; avoid prolonged light exposure.
This product offers dual orthogonal reactivity in a medium-length PEG spacer, making it an especially powerful tool for advanced click chemistry, bioconjugation, and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
