Mc-Val-Ala-PAB-PNP (CAS: 1639939-40-4) is a cleavable linker commonly used in antibody-drug conjugates (ADCs) for targeted drug delivery. It combines several functional components to ensure efficient drug release specifically within target cells:
- Mc (Maleimidocaproyl): Facilitates binding to thiol groups on proteins or antibodies.
- Val-Ala (Valine-Alanine): A dipeptide sequence cleaved by proteases like cathepsin B, enabling selective release in lysosomes.
- PAB (p-Aminobenzyl): A self-immolative spacer that releases the active drug upon Val-Ala cleavage.
- PNP (p-Nitrophenyl): Acts as a leaving group, aiding the conjugation process.
Applications:
- Antibody-Drug Conjugates (ADCs): Enables targeted delivery of cytotoxic drugs, reducing side effects.
- Targeted Cancer Therapeutics: Releases active agents within cancer cells, enhancing therapeutic effectiveness.
- Drug Delivery Research: Assists in designing delivery systems for controlled drug release.
Storage:
Store at -20°C, protected from light and moisture, to preserve stability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
