Maleimido-PEG4-Val-Ala-PAB-PNP CAS:2417003-94-0 is a type of small molecule linker that is commonly used in the field of bioconjugation and drug delivery. It contains several functional groups, including a maleimide group, a PEG (polyethylene glycol) chain, a valine-alanine dipeptide, a p-aminobenzyloxycarbonyl (PAB) protecting group, and a p-nitrophenyl (PNP) leaving group.
Maleimido-PEG4-Val-Ala-PAB-PNP is used to link two molecules together, typically a drug and a targeting agent or delivery vehicle. The maleimide group can react with thiol groups on the targeting agent or delivery vehicle, forming a stable thioether bond. The PEG chain improves the solubility and biocompatibility of the linker, while the dipeptide and PAB groups can be used to target specific cells or tissues.
The PNP leaving group can be cleaved under certain conditions, such as treatment with a reducing agent or UV light, to release the drug from the linker. This controlled release mechanism can improve the drug’s efficacy and reduce its toxicity, making it a promising candidate for targeted drug delivery in various diseases.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
