Maleimido-mono-amide-DOTA, CAS Number 1006711-90-5, is a versatile bioconjugation compound widely used in radiolabeling and molecular imaging.
Maleimido-mono-amide-DOTA Applications
- Bioconjugation: The maleimide group specifically reacts with thiol groups (-SH), enabling targeted attachment to cysteine residues in proteins and peptides.
- Radiolabeling: DOTA acts as a strong chelator, binding metal ions such as Gallium-68 for PET imaging or Lutetium-177 for targeted radiotherapy.
- Imaging: Commonly used to create imaging agents for PET, SPECT, and MRI, improving diagnostic accuracy in biomedical applications.
Properties
- Maleimide Group: Highly reactive with thiols, allowing site-specific labeling of biomolecules.
- Chelating Ability: DOTA forms stable complexes with metal ions, ensuring reliable and stable radiolabeling for imaging and therapeutic purposes.
Handling and Storage
- Storage: Store in a cool, dry place, away from light to maintain stability.
- Handling: Use standard protective equipment to prevent reactions with sensitive compounds during synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
