Mal-PEG8-acid
This product is a heterobifunctional linker containing a maleimide group, an eight-unit PEG spacer, and a terminal carboxylic acid. The maleimide reacts selectively with thiols to form stable thioether bonds, while the carboxyl group couples efficiently with amines or activated esters. The PEG8 chain improves solubility, flexibility, and spacing, making this reagent especially effective for bioconjugation, drug delivery, and probe development.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols for stable thioether linkages.
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Carboxylic Acid Group: Reacts readily with amines to form amide bonds.
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PEG8 Spacer: Provides solubility, reduced steric hindrance, and extended spacing.
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Dual Reactivity: Supports both thiol conjugation and amine coupling.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links thiol- and amine-containing biomolecules.
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Antibody–Drug Conjugates (ADCs): Functions as a bifunctional linker for controlled assembly.
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Drug Delivery: Serves as a PEGylated linker in therapeutic systems.
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Probe Development: Builds multifunctional probes with enhanced solubility.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines thiol-selective maleimide chemistry with amine-reactive carboxyl functionality in a PEG8 scaffold, specifically offering versatility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
