Mal-PEG4-bis-PEG3-DBCO is a dual-functional PEG linker designed for advanced bioconjugation and chemical biology. It includes a maleimide group for thiol-specific conjugation and two DBCO (dibenzocyclooctyne) groups for copper-free azide-alkyne cycloaddition (SPAAC). The PEG4 and bis-PEG3 linkers improve water solubility, flexibility, and reduce steric hindrance, making it ideal for a variety of biological and chemical applications.
Key Features
- Dual Functional Groups:
- Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
- DBCO: Enables strain-promoted, copper-free bioorthogonal reactions with azides.
- Enhanced PEG Linkers:
- PEG4 and bis-PEG3 enhance solubility and flexibility.
- Minimize steric interference for efficient conjugation.
- Biocompatibility:
- Non-toxic and ideal for use in biological systems.
Applications
- Bioconjugation:
- Attaches peptides, proteins, or nucleic acids via thiol and azide chemistry.
- Ideal for creating dual-functional biomolecular systems.
- Drug Delivery:
- Serves as a linker to improve pharmacokinetics and targeting in drug-conjugate systems.
- Nanotechnology:
- Functionalizes nanoparticles, biosensors, and medical implants for bioorthogonal labeling.
- Chemical Biology:
- Enables copper-free labeling and crosslinking in live-cell and in vivo systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
