Mal-PEG4-bis-PEG3-alkyne is a dual-functional PEG linker designed for advanced bioconjugation and chemical biology. It includes:
- A maleimide group for thiol-specific conjugation.
- Two terminal alkyne groups for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
The PEG4 and bis-PEG3 linkers improve solubility, flexibility, and reduce steric hindrance, making it ideal for diverse biological and chemical applications.
Key Features
- Functional Groups:
- Maleimide: Reacts specifically with thiol groups (-SH) to form stable thioether bonds.
- Alkynes: Enable efficient CuAAC (“click chemistry”) with azides.
- PEG Linkers:
- PEG4 and bis-PEG3 spacers enhance water solubility and flexibility.
- Minimize steric hindrance for efficient conjugation.
- Biocompatibility:
- Non-toxic and suitable for in vivo and in vitro applications.
Applications
- Bioconjugation: Links peptides, proteins, or other biomolecules via thiol and alkyne chemistry for multi-functional systems.
- Drug Delivery: Acts as a linker to improve the stability and solubility of drug conjugates.
- Nanotechnology: Functionalizes nanoparticles, biosensors, and surfaces for precise labeling and modifications.
- Chemical Biology: Enables site-specific labeling and complex molecule assembly using CuAAC.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
