Mal-PEG3-amine
This product is a heterobifunctional PEG3 linker featuring a maleimide for thiol-specific conjugation and a primary amine for coupling with carboxyl or NHS ester groups. The PEG3 spacer enhances solubility and flexibility, making this reagent especially versatile for bioconjugation, drug delivery, and multifunctional surface modification.
Key Features and Benefits:
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Maleimide Group: Reacts selectively with thiols to form stable thioether linkages.
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Amine Group: Couples efficiently with carboxyls, NHS esters, and electrophiles.
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PEG3 Spacer: Provides short hydrophilic spacing and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Supports orthogonal, stepwise synthetic strategies.
Applications:
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Bioconjugation: Enables thiol- and amine-based dual labeling of biomolecules.
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Drug Delivery: PEGylated linker improves solubility and stability of therapeutics.
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Antibody–Drug Conjugates (ADCs): Facilitates linker–payload attachment.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve maleimide and amine reactivity.
This product combines thiol-reactive and amine-reactive groups with a compact PEG spacer, making it an especially powerful tool for orthogonal bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
