Mal-PEG2-propargyl
This product is a heterobifunctional PEG linker featuring a maleimide group for selective thiol conjugation and a terminal propargyl group for click chemistry. The PEG2 spacer enhances solubility and flexibility, making it especially valuable for dual-functional bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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PEG2 Spacer: Provides solubility, hydrophilicity, and compact flexibility.
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Dual Reactivity: Supports orthogonal thiol and click conjugation.
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High Purity: Ensures reproducibility in sensitive applications.
Applications:
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Bioconjugation: Links thiol-containing biomolecules with alkyne-click handles.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Enables PEGylated, dual-reactive drug conjugates.
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Material Science: Functionalizes nanoparticles, polymers, and scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of maleimide.
This product combines thiol-reactive maleimide chemistry with a click-ready alkyne group in a PEG2 scaffold, specifically offering versatile functionality for bioconjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
