Mal-bis-PEG3-DBCO

Mal-bis-PEG3-DBCO

(Maleimide-bis-polyethylene glycol-DBCO, MW ~650 Da)

Chemical Information

• Structure: Contains a maleimide group for thiol-specific conjugation, a polyethylene glycol (PEG) linker with three PEG units, and a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC).

Key Features

1. Dual Functional Groups:
   • Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
   • DBCO: Reacts with azides without the need for copper catalysts, making it bioorthogonal.
2. PEG Linker:
   • Improves solubility and reduces steric hindrance in conjugation reactions.
3. Biocompatible:
   • Non-toxic and ideal for biological applications.

Applications

1. Bioconjugation:
   • Links biomolecules such as proteins, peptides, and nucleic acids via thiol and azide chemistry.
   • Enables dual functionalization of biomolecules for complex systems.
2. Drug Delivery:
   • Acts as a linker in drug-conjugate systems to improve solubility and targeting.
3. Nanotechnology:
   • Functionalizes nanoparticles and surfaces for biocompatible and bioorthogonal modifications.
4. Chemical Biology:
   • Facilitates bioorthogonal labeling and crosslinking in living systems.

Storage and Handling

• Storage: Store at -20°C in a dry, tightly sealed container, protected from light.
• Handling: Use gloves and avoid exposure to moisture to maintain reactivity.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.