Mal-amido-PEG8-acid
This product is a bifunctional PEG8 linker with a thiol-reactive maleimide on one end and a carboxylic acid on the other. The PEG8 spacer enhances solubility and flexibility, while the dual reactivity makes it highly useful for orthogonal bioconjugation, drug delivery, and surface functionalization.
Key Features and Benefits:
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Maleimide Group: Selectively couples with thiols for cysteine-specific conjugation.
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Carboxylic Acid Group: Forms stable amide bonds with amines.
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PEG8 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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High Purity: Suitable for sensitive, reproducible bioconjugation workflows.
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Dual Reactivity: Enables stepwise and orthogonal conjugation strategies.
Applications:
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Bioconjugation: Thiol-to-amine linkage for proteins, peptides, and biomolecules.
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Antibody-Drug Conjugates (ADCs): Commonly used in linker-payload design.
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Drug Delivery: Provides PEGylation for solubility and pharmacokinetic improvement.
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Surface Modification: Functionalize nanoparticles, hydrogels, or biosensors.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain reactivity.
This product provides dual-reactive handles with an optimized PEG spacer, making it an especially versatile linker for controlled and multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
