Mal-amido-PEG4-acid
This product is a heterobifunctional PEG4 linker with a thiol-reactive maleimide group and a terminal carboxylic acid. The PEG4 spacer provides hydrophilicity and short-to-medium chain flexibility, making it an especially excellent reagent for bioconjugation, drug delivery, and surface functionalization.
Key Features and Benefits:
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Maleimide Group: Selectively reacts with thiols to form stable thioether linkages.
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Carboxylic Acid Group: Couples efficiently with primary amines for amide bond formation.
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PEG4 Spacer: Provides solubility, reduced steric hindrance, and compact flexibility.
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High Purity: Ensures reproducibility in sensitive workflows.
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Dual Reactivity: Enables orthogonal, stepwise, and multifunctional conjugation.
Applications:
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Bioconjugation: Facilitates thiol–amine crosslinking for proteins, peptides, and biomolecules.
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Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biomaterials.
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Synthetic Chemistry: Serves as a versatile intermediate in dual-functional PEGylated scaffolds.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve maleimide and acid functionality.
This product combines thiol-selective and carboxyl-reactive groups in a PEG4 framework, making it an especially powerful tool for dual conjugation strategies and biomolecule engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
