Mal-amido-PEG2-amine
This product is a heterobifunctional PEG2 linker with a thiol-reactive maleimide group on one end and a primary amine on the other. The short PEG2 spacer imparts hydrophilicity and flexibility, while providing minimal steric hindrance, making this reagent highly useful for crosslinking, protein modification, and multifunctional bioconjugation.
Key Features and Benefits:
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Maleimide Group: Selectively reacts with thiols to form stable thioether linkages.
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Amine Group: Couples efficiently with carboxyls, NHS esters, and other electrophiles.
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PEG2 Spacer: Provides compact hydrophilicity and improved solubility.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Combines thiol-specific and amine-reactive chemistry for orthogonal strategies.
Applications:
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Bioconjugation: Facilitates dual-functional attachment of proteins, peptides, and biomolecules.
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Crosslinking: Links thiol- and amine-containing molecules with precision.
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Drug Delivery: PEGylated linker improves solubility and stability in therapeutic constructs.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve maleimide and amine stability.
This product combines thiol-specific maleimide chemistry with amine reactivity in a compact PEG2 framework, making it an especially excellent tool for bioconjugation, crosslinking, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
