m-PEG8-Ms
This product is a mesylate-activated PEG derivative with eight ethylene glycol units and a terminal methyl-capped end. The mesyl (methanesulfonyl) group acts as an excellent leaving group, allowing nucleophilic substitution to generate diverse PEG-functionalized molecules. The PEG8 spacer provides solubility, flexibility, and biocompatibility, making it an especially valuable intermediate for bioconjugation and advanced synthesis.
Key Features and Benefits
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Mesylate Group (Ms): Highly reactive leaving group, ideal for substitution with amines, thiols, and alkoxides.
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PEG8 Spacer: Offers solubility, flexibility, and reduced steric hindrance in conjugation workflows.
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Monomethyl-Capped: Prevents crosslinking, ensuring single-point reactivity.
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Synthetic Versatility: Converts easily to PEG-amines, PEG-thiols, PEG-alcohols, and other derivatives.
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High Purity: Produced to ≥95% purity for reliable and reproducible synthetic applications.
Applications
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PEG Derivatization: Precursor for a wide range of PEG-based linkers and reagents.
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Bioconjugation: Supports PEGylation strategies for proteins, peptides, and small molecules.
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Surface Modification: Functionalizes polymers, nanoparticles, and biomaterials to improve biocompatibility.
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Organic Synthesis: Useful intermediate for advanced multifunctional PEG reagents.
Storage and Handling
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Storage: Keep at –20 °C in a sealed container, away from light and moisture.
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Handling: Use under inert atmosphere when possible; prepare solutions fresh before use.
This product combines a mesylate leaving group with an eight-unit PEG chain, making it an especially versatile intermediate for nucleophilic substitution and PEGylation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
