m-PEG-Ms linker bears a tosyl group. The tosyl group can be easily replaced by thiol and amino group through a nucleophilic substitution.The mPEG increases the aqueous solubility of the resulting compound.
m-PEG-Ms linker is a commonly used molecule in pharmaceutical research and development. It is a type of polyethylene glycol (PEG) molecule that contains a methanesulfonate (Ms) functional group at one end. The Ms group is a reactive group that can be used to link the m-PEG-Ms molecule to other molecules, such as proteins, peptides, or drugs. This linkage can be used to modify the properties of the other molecule, such as increasing its solubility, stability, or bioavailability.
The m-PEG-Ms linker is widely used in pharmaceutical research and development. One of its main applications is in the development of biopharmaceuticals, such as protein or peptide therapeutics. These molecules often have poor pharmacokinetic properties, such as short half-lives or poor solubility. The m-PEG-Ms linker can be used to modify these molecules to improve their properties, such as increasing their half-life or solubility.
Another application of the m-PEG-Ms linker is in drug delivery. The linker can be used to attach drugs to carrier molecules, such as nanoparticles or liposomes, to improve their pharmacokinetic properties and target specific tissues or cells.