m-PEG7-Propargyl
Chemical Information
- Molecular Formula: C₁₀H₂₀O₄
- Structure: Composed of a methoxy-terminated polyethylene glycol chain with 7 ethylene glycol units and a terminal propargyl group (-C≡CH).
Key Features
- Propargyl Functional Group:
- Reacts with azides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) in “click chemistry” applications.
- Offers specificity for conjugation reactions.
- Polyethylene Glycol Chain:
- Improves solubility and biocompatibility of conjugated molecules.
- Provides flexibility and hydrophilicity.
- Controlled Length:
- 7 PEG units (~350 Da) ensure consistent and predictable performance.
m-PEG7-Propargyl Applications
- Bioconjugation:
- Used to attach biomolecules such as peptides, proteins, and nucleic acids via click chemistry.
- Improves solubility and stability of conjugates.
- Drug Delivery:
- Acts as a linker or spacer for drug-conjugate systems.
- Enhances pharmacokinetic properties of drugs.
- Surface Modification:
- Functionalizes surfaces of nanoparticles, biosensors, and medical devices to reduce non-specific interactions.
- Polymer Research:
- Incorporates into PEG-based materials for hydrogels, block copolymers, and micelles.
Storage and Handling
- Storage: Store in a cool, dry place, away from light and moisture.
- Handling: Use proper protective equipment and handle in a well-ventilated area.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
