m-PEG13-Ms
m-PEG13-Ms is a monofunctional PEG linker with a methoxy end group, a PEG13 spacer, and a mesyl group. The mesyl group acts as an excellent leaving group, specifically enabling nucleophilic substitution for custom PEG derivatives in synthesis and bioconjugation.
Key Features and Benefits
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Mesyl Group: Highly reactive leaving group for substitution with thiols, amines, or alkoxides.
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PEG13 Spacer: Provides extended solubility, hydrophilicity, and molecular flexibility.
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Methoxy End-Cap: Enhances stability and minimizes nonspecific interactions.
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Reactive Intermediate: Serves as a precursor for functionalized PEG-based linkers.
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High Purity: Ensures reproducible results in sensitive workflows.
Applications
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Organic Synthesis: Generates functional PEG derivatives via mesyl substitution.
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Bioconjugation: Builds PEGylated linkers for proteins, peptides, and small molecules.
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Drug Delivery: Creates PEG scaffolds for improved solubility and circulation.
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Material Science: Introduces PEG functionality into polymers and nanostructures.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product combines a mesyl leaving group with a long PEG13 chain, specifically providing a reactive and highly soluble intermediate for linker synthesis, bioconjugation, and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
