m-PEG12-DBCO
This product is a monofunctional PEG12 linker terminated with a dibenzocyclooctyne (DBCO) group. The PEG12 spacer enhances solubility and flexibility, while the DBCO enables rapid, copper-free click chemistry with azides (SPAAC), making it highly valuable for bioorthogonal labeling, drug delivery, and surface functionalization.
Key Features and Benefits:
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DBCO Group: Supports strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG12 Spacer: Provides hydrophilicity, extended spacing, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive labeling and bioconjugation workflows.
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Copper-Free Reactivity: Compatible with live-cell and in vivo applications.
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Balanced Length: PEG12 chain offers moderate solubility and flexibility.
Applications:
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Click Chemistry: SPAAC conjugation with azide-containing biomolecules.
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Bioconjugation: Label proteins, peptides, and antibodies with high selectivity.
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Drug Delivery: Useful in linker–payload systems for targeted therapeutics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain DBCO reactivity.
This product provides a copper-free click handle with a hydrophilic PEG12 spacer, making it an especially versatile reagent for advanced bioconjugation and drug delivery strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
