Laurdan (6-Dodecanoyl-2-dimethylaminonaphthalene, CAS: 74515-25-6) is a fluorescent probe used to study cell membrane dynamics and lipid phase transitions. Its emission properties change based on the surrounding membrane environment, making it ideal for assessing membrane fluidity and lipid packing.
Key Features:
- Polarity Sensitivity: Laurdan’s fluorescence shifts from ~440 nm in gel-phase membranes to ~490 nm in liquid-phase membranes.
- Generalized Polarization (GP): Measures membrane fluidity and lipid packing, aiding in the detection of lipid rafts and membrane microdomains.
Applications:
- Membrane Studies: Analyzes membrane fluidity, lipid phases, and membrane organization in live or fixed cells.
- Fluorescence Microscopy: Enables multiphoton imaging of lipid rafts and membrane order in tissues.
Handling and Storage:
- Solubility: Dissolves in DMF, acetonitrile, and methanol.
- Storage: Keep at -20°C, protected from light, to maintain stability.
Laurdan’s unique ability to detect changes in membrane polarity makes it invaluable for cell membrane research and fluorescence imaging studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
