HyNic-PEG2-Azide
This product is a heterobifunctional PEG2 linker with a hydrazinonicotinamide (HyNic) group and a terminal azide. The HyNic group enables hydrazone formation with aldehydes or ketones, while the azide supports bioorthogonal click chemistry with alkynes, making this reagent highly versatile for dual-conjugation strategies.
Key Features and Benefits:
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HyNic Group: Forms stable hydrazone linkages with aldehyde or ketone groups.
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Azide Group: Enables CuAAC and SPAAC click chemistry with alkynes.
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PEG2 Spacer: Provides compact hydrophilicity and flexibility with minimal steric hindrance.
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High Purity: Ensures reproducibility in bioconjugation workflows.
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Orthogonal Reactivity: Supports multifunctional and stepwise conjugation.
Applications:
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Bioconjugation: Dual-reactive linker for proteins, peptides, and glycoproteins.
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Click Chemistry: Bioorthogonal labeling via azide–alkyne ligation.
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Glycoconjugation: Facilitates selective modification of oxidized sugars.
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Drug Delivery: PEGylated scaffold enhances solubility and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve azide and HyNic stability.
This product combines hydrazone chemistry with click-ready azide reactivity, making it an especially efficient and flexible reagent for multifunctional conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.