HO-PEG20-t-butyl ester
This product is a heterobifunctional PEG reagent featuring a terminal hydroxyl group and a t-butyl ester as an acid-labile protecting group. The long PEG20 chain provides excellent solubility, flexibility, and spacing, making it especially valuable for orthogonal conjugation, bioconjugation, and drug delivery.
Key Features and Benefits:
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Hydroxyl Group: Serves as a versatile handle for further derivatization.
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t-Butyl Ester: Acid-labile protection enables controlled deprotection.
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PEG20 Spacer: Provides high solubility, hydrophilicity, and extended spacing.
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Orthogonal Reactivity: Supports stepwise, multifunctional synthesis.
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High Purity: Ensures reliable results in sensitive applications.
Applications:
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Bioconjugation: Introduces hydroxyl and protected ester handles to biomolecules.
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Drug Delivery: Provides long PEG scaffolds for improved pharmacokinetics.
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Probe Development: Builds multifunctional imaging and diagnostic tools.
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Synthetic Chemistry: Useful intermediate for orthogonal synthetic schemes.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); deprotect t-butyl ester under acidic conditions.
This product combines hydroxyl functionality with a protected ester in a PEG20 scaffold, specifically offering high solubility and flexibility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
