HO-PEG24-t-butyl ester
HO-PEG24-t-butyl ester is a high-purity monofunctional PEG with a hydroxyl group and an acid-labile tert-butyl ester linked by a PEG24 spacer. The hydroxyl allows versatile coupling, while mild acid cleavage of the tert-butyl ester yields a carboxylic acid. The long PEG chain offers exceptional hydrophilicity, reach, and flexibility, especially ideal for bioconjugation, surface modification, and polymer–drug conjugates in aqueous and organic systems.
Key Features
-
Monofunctional PEG with hydroxyl and tert-butyl ester termini
-
Selective acid-labile deprotection to carboxylic acid
-
PEG24 spacer offers superior solubility, flexibility, and low steric hindrance
-
High chemical purity for reproducible performance
Applications
-
Protein, peptide, and antibody conjugation
-
Polymer–drug conjugates and prodrug synthesis
-
Surface and nanoparticle functionalization
-
Linker design for diagnostics and therapeutics
Storage and Handling
-
Store at –20 °C, protected from light and moisture
-
Equilibrate to room temperature before opening
-
Avoid repeated freeze–thaw cycles
This product combines a hydroxyl group for functionalization with an acid-labile tert-butyl ester, linked by a long PEG24 chain specifically for maximum hydrophilicity and reach.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
