Glutaric Acid (CAS 110-94-1) is a dicarboxylic acid featuring reactive carboxyl groups at both ends. These groups easily form stable amide bonds with primary amines when using activators like EDC or HATU. This makes glutaric acid ideal for modifying drugs to enhance solubility, release, and antinociceptive activity.
Additionally, glutaric acid acts as a spacer in bioconjugates, boosting intracellular uptake. This improved flexibility enhances drug delivery and molecular interactions.
Key Properties:
- Molecular Formula: C₅H₈O₄
- Molecular Weight: 132.11 g/mol
- Melting Point: 95-98°C
- Solubility: Soluble in water, alcohol, and chloroform
- Appearance: White to off-white crystalline powder
Glutaric Acid Applications:
- Prodrug Development: Enhances drug solubility and controlled release.
- Bioconjugation: Serves as a spacer to improve uptake of bioconjugates.
- Amide Bond Formation: Links with amines for stable chemical synthesis.
- Polymer Synthesis: A critical building block for polyesters and polyamides.
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