Folate-PEG3-Propargyl
This product is a high-purity heterobifunctional linker with a folate moiety for targeting folate receptors and a terminal propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG3 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient conjugations in aqueous and organic systems. This reagent is especially ideal for targeted drug delivery, imaging probes, and nanoparticle functionalization.
Key Features and Benefits
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Folate Moiety: Enables high-affinity targeting of folate receptor–positive cells.
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Propargyl Group: Compatible with CuAAC click chemistry for selective conjugation with azides.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Targeted drug delivery to folate receptor–expressing cells.
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Imaging and diagnostic probe development.
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Nanoparticle and liposome functionalization.
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Bioconjugation in therapeutic and research applications.
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Site-specific labeling using click chemistry.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve propargyl reactivity.
This product combines folate receptor targeting with propargyl click chemistry, linked by a PEG3 spacer specifically for solubility and flexibility in targeted bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
