Fmoc-NH-PEG6-acid
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a six-unit PEG spacer, and a terminal carboxylic acid. The Fmoc group offers orthogonal protection for peptide synthesis, removable under mild base conditions, while the carboxyl couples efficiently with amines or activated esters. The PEG6 chain provides solubility, flexibility, and medium-range spacing, making this reagent especially useful in peptide synthesis, bioconjugation, and drug delivery.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis; removable with mild base.
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Carboxylic Acid Group: Couples readily with amines for amide bond formation.
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PEG6 Spacer: Improves solubility and reduces steric hindrance.
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Orthogonal Design: Supports stepwise synthesis and multifunctional strategies.
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High Purity: Produced to ≥95% purity for reliable results.
Applications
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Peptide Synthesis: Incorporates PEG spacers into peptides by SPPS.
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Bioconjugation: Links proteins, probes, or carriers through amine/acid chemistry.
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Drug Delivery: Serves as a PEGylated linker for therapeutic conjugates.
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Probe Development: Builds multifunctional probes with enhanced solubility.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions.
This product combines an orthogonally protected amine with a carboxyl handle on a PEG6 scaffold, specifically offering versatility for controlled synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
