Fmoc-NH-PEG16-acid
This product is a heterobifunctional PEG linker featuring an Fmoc-protected amine, a sixteen-unit PEG spacer, and a terminal carboxylic acid. The Fmoc group provides orthogonal protection, removable under mild base conditions, while the carboxyl group couples efficiently with primary amines or activated esters. The PEG16 chain offers excellent solubility, flexibility, and long-range spacing, making this reagent especially useful for peptide synthesis, bioconjugation, and therapeutic development.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis; removable with mild base.
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Carboxylic Acid Group: Couples readily with amines for amide bond formation.
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PEG16 Spacer: Provides long hydrophilic spacing with reduced steric hindrance.
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Orthogonal Reactivity: Enables stepwise peptide synthesis and multifunctional conjugation.
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High Purity: Produced to ≥95% purity for consistent performance.
Applications
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Peptide Synthesis: Adds long PEG spacers to peptides via SPPS.
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Bioconjugation: Couples proteins, antibodies, or probes through amine/acid chemistry.
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Drug Delivery: Improves solubility and circulation of therapeutic conjugates.
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Probe Development: Creates multifunctional probes with extended spacing.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove Fmoc under standard SPPS conditions; prepare fresh solutions before use.
This product combines orthogonal Fmoc protection with a reactive carboxyl group on a long PEG16 backbone, specifically providing an extended, flexible linker for bioconjugation and synthetic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
