Fmoc-NH-PEG15-acid
This product is a heterobifunctional PEG linker featuring an Fmoc-protected amine, a fifteen-unit PEG spacer, and a terminal carboxylic acid. The Fmoc group offers orthogonal protection, removable under mild base conditions, while the carboxyl couples efficiently with amines or activated esters. The PEG15 chain provides excellent solubility, flexibility, and extended spacing, making this reagent especially effective for peptide synthesis, bioconjugation, and therapeutic development.
Key Features and Benefits
-
Fmoc-Protected Amine: Stable during synthesis; removable under mild base conditions.
-
Carboxylic Acid Group: Couples efficiently with amines for amide bond formation.
-
PEG15 Spacer: Provides long-range spacing, hydrophilicity, and flexibility.
-
Orthogonal Design: Supports controlled peptide synthesis and multifunctional conjugation.
-
High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
-
Peptide Synthesis: Introduces extended PEG spacers into peptides via SPPS.
-
Bioconjugation: Couples proteins, antibodies, or probes through acid/amine chemistry.
-
Drug Delivery: Serves as a PEGylated linker to improve solubility and circulation.
-
Probe Development: Builds multifunctional probes with extended spacing.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, desiccated container.
-
Handling: Remove Fmoc under standard SPPS conditions; prepare fresh solutions before use.
This product combines orthogonal Fmoc protection with a reactive carboxyl group on a PEG15 backbone, specifically offering a long, flexible spacer for advanced conjugation and synthetic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
