Fmoc-NH-PEG1-acid (CAS 1654740-73-4)
Fmoc-NH-PEG1-acid is a PEG derivative with an Fmoc-protected amine and a carboxylic acid, enhancing water solubility for versatile chemical and biomedical use. The Fmoc group is easily removed under basic conditions, freeing the amine for further conjugation. The carboxylic acid readily forms stable amide bonds with amines under coupling conditions like EDC, DCC, or HATU.
Key Features:
- Molecular Formula: C₂₀H₂₁NO₅
- Molecular Weight: 355.39 g/mol
- Functional Groups: Fmoc-protected amine and carboxylic acid
- Solubility: Soluble in organic solvents like DMF and DMSO
Applications:
- Peptide Synthesis: The Fmoc group protects amines during solid-phase peptide synthesis, allowing for sequential amino acid additions.
- PROTAC Development: Acts as a linker in PROTAC synthesis, connecting target protein ligands with E3 ubiquitin ligase ligands.
- Drug Delivery Research: The PEG moiety enhances solubility and biocompatibility, aiding drug delivery systems.
- Bioconjugation: The carboxylic acid forms stable amide bonds with primary and secondary amines, facilitating biomolecule conjugation.
Handling and Storage:
- Storage Conditions: Store at -20°C in a dry, light-protected environment.
- Handling Precautions: Use personal protective equipment and ensure proper ventilation during handling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
