Fmoc-NH-PEG-Mal, MW 3.4K is a polymer that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains three functional groups: an Fmoc group, an N-terminal amine group, and a maleimide group (-Mal) attached to the PEG chain. The Fmoc group is a protecting group that can be easily removed using basic conditions to reveal the N-terminal amine group, while the maleimide group is known for its ability to react with thiols through a Michael addition reaction, making Fmoc-NH-PEG-Mal,MW 3.4K a valuable tool in the field of pharmaceutical research and development.
Fmoc-NH-PEG-Mal, MW 3.4K has been extensively used in the development of novel drug conjugates and bioconjugation reactions. Its unique chemical properties allow for the selective and covalent attachment of therapeutic agents, such as proteins and peptides, to the N-terminal amine group of the PEG chain via maleimide-thiol coupling. This enables the production of stable and homogeneous drug conjugates that exhibit improved pharmacokinetic and pharmacodynamic properties, as well as reduced immunogenicity and toxicity.
Furthermore, Fmoc-NH-PEG-Mal, MW 3.4K can also be used as a versatile building block for the synthesis of functionalized PEG-based materials, such as hydrogels, nanoparticles, and micelles. The maleimide group can be used to introduce a variety of functional groups onto the PEG chain, allowing for the modulation of material properties such as solubility, biocompatibility, and mechanical strength.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
