Fmoc-aminooxy-PEG12-acid
This product is a heterobifunctional PEG linker containing an Fmoc-protected aminooxy group, a PEG12 spacer, and a terminal carboxylic acid. It specifically enables orthogonal deprotection, oxime ligation, and amide coupling, offering solubility, extended flexibility, and multifunctional reactivity.
Key Features and Benefits
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Fmoc-Protected Aminooxy: Allows selective deprotection for oxime ligation with aldehydes and ketones.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PEG12 Spacer: Provides long-chain flexibility, solubility, and reduced steric hindrance.
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Dual Reactivity: Combines protected aminooxy chemistry with carboxyl functionality.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links carbonyl-containing biomolecules with amine-modified partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with solubility and orthogonal reactivity.
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Organic Synthesis: Serves as a versatile intermediate in linker chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates protected aminooxy chemistry with carboxyl reactivity in a PEG12 scaffold, specifically offering solubility, flexibility, and multifunctional conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
