exo-BCN-Val-Cit-PAB-PNP
This product is a cleavable linker that specifically enables copper-free tetrazine click ligation, Val-Cit is cathepsin B–cleavable, PAB supports self-immolative release, and PNP ester allows coupling with hydroxyls or amines.
Key Features and Benefits
-
exo-BCN Group: Supports ultrafast, copper-free click reactions with tetrazines.
-
Val-Cit Dipeptide: Protease-cleavable sequence recognized by cathepsin B.
-
PAB Spacer: Ensures efficient and controlled payload release.
-
PNP Ester: Couples readily with hydroxyls or amines for stable conjugation.
-
High Purity: Produced to ≥95% purity for reproducible bioconjugation.
Applications
-
Antibody–Drug Conjugates (ADCs): Serves as a bioorthogonal, cleavable linker for targeted drug release.
-
Drug Delivery: Facilitates intracellular payload release upon protease cleavage.
-
Probe Development: Builds multifunctional cleavable probes for imaging and diagnostics.
-
Bioconjugation: Links therapeutic or diagnostic molecules with controlled release.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product integrates bioorthogonal click chemistry, protease-cleavable design, and efficient payload release, making it an especially powerful tool for ADC development and targeted bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
