FmocEVCit-PAB-PNP
This product is a multifunctional cleavable linker containing an Fmoc-protected valine-citrulline (EVCit) dipeptide, a PAB spacer, and a p-nitrophenyl (PNP) ester. It specifically enables enzymatic cleavage, controlled drug release, and efficient amine coupling.
Key Features and Benefits
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Fmoc-Protected EVCit: Serves as an enzyme-cleavable linker for drug release.
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PAB Spacer: Provides self-immolative cleavage for payload release.
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PNP Ester: Couples efficiently with amines to form stable amide bonds.
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Cleavable Design: Supports controlled intracellular release in targeted systems.
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High Purity: Ensures reproducibility in drug development and conjugation workflows.
Applications
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ADC Development: Provides a cleavable linker for antibody–drug conjugates.
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Drug Delivery: Enables targeted release of cytotoxic or therapeutic payloads.
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Probe Development: Builds enzyme-cleavable probes for chemical biology.
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Medicinal Chemistry: Supports design of cleavable conjugates for therapy and research.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates an enzyme-sensitive EVCit linker with a PAB spacer and PNP ester, specifically enabling efficient conjugation and controlled release applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
