ADC Technologies & Analytical Services & Worldwide Leading PEG Supplier
Facebook Twitter YouTube linkedin
1-858-677-9432
sales@axispharm.com
Hello, Sign in
Tracking & Orders
1-858-677-9432
sales@axispharm.com
AxisPharm AxisPharm
  • Home
  • Services
    • Service Area
      • Proteomics Services
        • DIA Proteomics Services
        • Intact Protein Analysis
        • Label Free Protein Quantification and Identification
        • Protein sequencing and quantification – TMT
        • Post Translational Modification Analysis
      • Metabolomics Services
        • Targeted Metabolomics Services
          • Amino Acid Panel
          • Bile Acid Panel
          • Carbohydrates Panel
          • Free Fatty Acid Panel
          • Lipids Panel
          • Steroid Hormones Panel
        • Untargeted Metabolomics Services
      • Lipidomics Services
      • Analytical Services
      • Bioconjugation Service
        • Formulation Services
        • Custom Synthesis Services
    • Service Area
      • Bioanalytical Services
        • Bioanalytical Method Development and Validation Services
        • Non-GLP and Discovery Bioanalysis Services
        • Bioanalytical Mass Spectrometry Services
        • In Vitro ADME Services
        • In Vivo DMPK Analysis Services
        • Ligand Binding Assay Bioanalysis Services
      • In Vitro Diagnostic (IVD) Research and Development
        • Chemiluminescence immunoassay (CLIA)
        • Enzyme-linked immunosorbent assay (ELISA)
        • Fluorescence immunoassay (FIA)
        • Latex-enhanced immunoturbidimetry (LETIA)
    • Test Type
      • HRMS and LC-HRMS Analysis Services
      • ICP-MS Analysis Services
      • Ion Chromatography – HPIC
      • LCMS Analysis
      • LCMSMS Analysis
      • GCMS Analysis
      • Maldi-TOF Analysis
      • Q-TOF-LC-MS and TQ-LC-MS analysis of Oligonucleotides
      • Titrations
    • Analyte Type
      • Chemical Testing
      • Small Molecule Analysis
      • Protein
      • Oligonucleotides
      • Polymers
      • Consumer Products Analysis
      • Environmental Analysis
      • Forensic
      • Pharmaceutical
  • Products
    • PEG Linkers
    • Lipids for Drug Delivery
    • Fluorescent Dye
    • Click Chemistry Reagents
    • Poly-PEG,Copolymer
    • Cleavable Linkers
    • Antibody-and-antibody-drug-conjugate-adc
    • ADC Payloads
    • Cell Biology Reagents
    • DNA
    • Modifier
    • Probes
    • Synthetic-peptides
    • Thiol reactive
    • Acid reactive
    • Amine reactive
    • Carbonyl reactive
    • Acid PEG
    • Aldehyde PEG
    • Alkyne PEG
    • Amino PEG
    • Aminooxy PEG
    • APN Linkers
    • Azide PEG
    • BCN-PEG
    • Benzyl-PEG
    • Biotin PEG
    • Bis-PEG-NHS
    • Bis-PEG-acid
    • Bis-Sulfone PEG
    • Boc-PEG
    • Branched PEG
    • Bromo PEG
    • Cleavable Linkers
    • DBCO PEG
    • DNP PEG
    • DOTA PEG
    • DSPE PEG
    • Diketone PEG
    • Fluorescent PEG
    • Fmoc PEG
    • Folate PEG
    • Homobifunctional PEG
    • HyNic PEG
    • Hydrazide PEG
    • Hydroxy PEG
    • Iodo PEG
    • Lipid PEG
    • M-PEG
    • Maleimide PEG
    • MeNH-PEG
    • NHS ester PEG
    • Non-PEG linker
    • PEG-X-PEG
    • PEG-t-butyl ester
    • PFP ester PEG
    • PROTAC PEG
    • Peptide Linkers
    • Phosphonate PEG
    • Polymer PEG
    • Propargyl PEG
    • SPDP PEG
    • Silane PEG
    • Sugar PEG
    • Sulfonic acid PEG
    • TCO PEG
    • Tetrazine PEG
    • Thiol PEG
    • Tosylate PEG
    • PEG Linkers By Modular Weight
    • Biotinyl Cap PE
    • Biotinyl PE
    • Caproylamine PE
    • Cationic Lipid
    • Cyanur PE
    • Dodecanyl PE
    • Glutaryl PE
    • Ionizable Lipid
    • MPB PE
    • PDP PE
    • PE MCC
    • Phosphatidylcholine
    • Phosphatidylethanolamine
    • Phosphoglycerol
    • Phosphoserine
    • Ptd Thioethanol
    • Succinyl PE
    • Lipid-PEG
    • APDye Fluors
      • APDye Fluor 350
      • APDye Fluor 405
      • APDye Fluor 430
      • APDye Fluor 488
      • APDye Fluor 532
      • APDye Fluor 546
      • APDye Fluor 555
      • APDye Fluor 568
      • APDye Fluor 594
      • APDye Fluor 633
      • APDye Fluor 647
      • APDye Fluor 660
      • APDye Fluor 680
      • APDye Fluor 800
    • Cyanine Dyes
      • Cyanine 3 Dye
      • Cyanine3.5 Dye
      • Cyanine5 Dye
      • Cyanine5.5 Dye
      • Cyanine7 Dye
      • Cyanine7.5
      • Sulfo Cyanine3 Dye
      • Sulfo Cyanine5 Dye
      • Sulfo-Cyanine3.5
      • sulfo-Cyanine5.5
      • sulfo-Cyanine7
      • sulfo-Cyanine7.5
    • MB Dyes
      • MB 488 Dye
      • MB 532 Dye
      • MB 543 Dye
      • MB 594 Dye
      • MB 633 Dye
      • MB 660R Dye
      • MB 680R Dye
      • MB 700R Dye
      • MB 800Z Dye
    • Others
      • AF Dyes
      • Bodipy Probes
      • Classic Fluorescent Dyes
      • Coumarin 343
      • DNP PEG
      • Fluorescein(FAM)
      • Haptens
      • IR Fluors
      • JOE
      • MB Dyes
      • Peptide Labeling Reagents
      • Pyrene Probes
      • Quenchers
      • R6G
      • Rhodamine Dye
      • Rox Dye
      • TAMRA Dye
    • Alkyne PEG
    • BCN-PEG
    • DBCO PEG
    • Methylcyclopropene-linkers
    • TCO-PEG
    • Tetrazine-PEG
    • PTDA Linkers
    • Azide PEG
    • Click Chemistry Auxiliary Reagents
    • Acrylate
    • Active ester
    • Aldehyde
    • Amine
    • Azide
    • Biotin
    • Boc
    • Carboxylic acid
    • Cholesterol
    • DBCO
    • Fmoc
    • Folate
    • Hydrazide
    • Hydroxyl
    • Lipoamide
    • Maleimide
    • Polysarcosine
    • Silane
    • Stearic acid
    • TCO
    • Thiol
    • -S-S- Cleavable
    • Cleavable Peptide
    • Dde Cleavable Linkers
    • Disulfide Biotin
    • PC Cleavable
    • Photocleavable Biotin
    • diazo biotin probes
    • β-Glucuronide Linkers
    • DTSSP crosslinker
    • Antibody
    • Antibody-drug-conjugates
    • Payloads and Linker modified Payloads
    • Cell Biology Reagents
    • CPG Solid Supports
    • Modified Triphosphates
    • PCR/qPCR stain
    • Phosphoramidite
    • Drug Formulation
    • Surface Modifier
    • Biotin PEG
    • Fluorescent Dye
    • Folate PEG
    • Image Probes
    • PROTAC PEG
    • Synthetic-peptides
    • Bromo PEG
    • Cleavable PEG
    • PEG Maleimide
    • PEG Tosylate
    • Amino PEG
    • Aminooxy PEG
    • MeNH-PEG
    • Bromo PEG
    • PEG Acid
    • PEG Aldehyde
    • PEG Maleimide
    • PEG NHS ester
    • PEG Tosylate
    • Aminooxy PEG
    • PEG hydrazide
    • Polyethylene Glycol PEG Linkers
    • Cleavable Linkers
    • Amine reactive Linkers
    • Acid reactive Linkers
    • Thiol reactive Linkers
    • Carbonyl reactive Linkers
    • Modifier
    • Probes
    • Other Linkers
  • Instrumentation
    • Agilent 1290 Infinity UPLC/ AB Sciex 5500 Qtrap Mass Spectrometer
    • Bruker timsTOF Pro 2
    • Bruker Autoflex Max MALDI-TOF MS
    • Orbitrap Fusion Lumos Tribrid Mass Spectrometer
    • Orbitrap Mass Spectrometer
    • GCMS
    • ICP-MS
    • Ion Chromatography – HPIC
    • LCMS
    • Maldi-TOF
    • Q-TOF-LC-MS and TQ-LC-MS
    • Titrations
    • TOF and QTOF Mass Spectrometer
  • Quick Links
    • Sample Preparation Guidelines
    • Online Sample Submission
    • Sample Submission Form (PDF)
    • GCMS GCFID Pricing
    • Analytical Pricing
    • PK Study Pricing
    • Proteomics Pricing
    • Metabolomics Services Pricing
    • Protocols
  • Blog
  • Contact Us
    • About Us
    • Product Support
    • Services and Products Cited
    • Videos
    • News
    • FAQ
    • Careers
0 items / $0.00
Menu
AxisPharm AxisPharm
0 items / $0.00
HomeOther LinkersNew ProductsNew PEG Linkers FmocEVCit-PAB-PNP
Previous product
FmocEVCit-PAB $870.00 – $3,000.00
Back to products
Next product
CAS:2249926-65-4
DBCO-PEG3-CH2CO2H $300.00 – $1,440.00
FmocEVCit-PAB-PNP

Catalog #: AP10028
Name: FmocEVCit-PAB-PNP
Chemical Formula: C49H57N7O13
Molecular Weight: 952.02
Purity: ≥95%
Availability: In Stock
SDS: Download

FmocEVCit-PAB-PNP

$1,200.00 – $3,900.00

The glutamic acid–valine–citrulline (EVCit) linker offers enhanced stability and effectiveness for antibody–drug conjugates (ADCs). Unlike traditional VCit linkers, EVCit maintains stability in plasma, reduces premature drug release, and ensures effective payload delivery. This advancement leads to improved antitumor efficacy and reliability in preclinical models, making EVCit a promising choice for more effective cancer therapies.

UnitPriceQuantity
50mg$1200
100mg$1950
250mg$3900

Would you like to inquire about bulk pricing?

Bulk inquiry
SKU: AP10028 Category: New PEG Linkers Tag: hot
Share
Facebook Twitter Pinterest linkedin
  • Description
  • Synonyms
  • Shipping & Delivery
Description

Glutamic Acid–Valine–Citrulline (EVCit) Linker: Enhancing ADC Stability and Effectiveness

Overview of ADCs

Antibody–drug conjugates (ADCs) are revolutionizing cancer treatment by combining monoclonal antibodies with potent cytotoxic drugs. FDA-approved ADCs like Adcetris® and Kadcyla® have shown significant clinical success. However, the effectiveness of ADCs depends heavily on the choice of linker used to attach the drug to the antibody.

Challenges with Traditional Linkers

Valine–citrulline (VCit) linkers are popular for their ability to release drugs upon reaching target cells. Despite this, VCit linkers are unstable in mouse plasma due to hydrolysis by carboxylesterase 1c (Ces1c), leading to premature drug release and unreliable preclinical results.

Introducing EVCit Linker

The glutamic acid–valine–citrulline (EVCit) linker addresses the stability issues of VCit linkers:

  • Enhanced Plasma Stability: EVCit linkers maintain stability in both mouse and human plasma, minimizing premature drug release.
  • Effective Payload Release: EVCit still allows for efficient drug release inside target cells through cathepsin-mediated cleavage.
  • Improved Efficacy: ADCs with EVCit linkers show superior antitumor effects in preclinical models compared to those with VCit linkers.

Key Benefits of EVCit Linkers

  1. Greater Stability: Reduces the risk of early drug release, improving the accuracy of preclinical evaluations.
  2. Reliable Payload Delivery: Ensures effective release of the drug inside target cells.
  3. Enhanced Therapeutic Performance: Demonstrates better efficacy in animal models, offering promising results for future clinical applications.
  4. Versatile Application: Suitable for a range of molecular drug conjugates beyond ADCs.

Conclusion

Ref:

Anami, Y., Yamazaki, C.M., Xiong, W. et al. Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice. Nat Commun 9, 2512 (2018). https://doi.org/10.1038/s41467-018-04982-3.

AxisPharm maintain Fmoc-EVCit-PAB linker in stock and can custom synthesize corresponding pegylated EVCit-PAB linker with competitve price.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.

Synonyms
  • Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
Shipping & Delivery
Ships within: 24 hours
Storage condition: -20 ° C
Shipping: Ambient Temperature

Related products

Cat# Name Structure M.W. Purity Pricing
AP10773N,N-Bis(PEG1-amine)-N-Boc
Quick viewN,N-Bis(PEG1-amine)-N-Boc
291.39≥95% Pricing
M.W: 291.39; Purity: ≥95%
N,N-Bis(PEG1-amine)-N-Boc
Unit Price(USD)Quantity & Buy
100 mg$580
250 mg$1160
500 mg$1740
1 g$2610
Bulk inquiry

Inquire about bulk pricing for large orders!

AP108664-mercapto-4-methylpentanoic acid
Quick view4-mercapto-4-methylpentanoic acid
148.22≥95% Pricing
M.W: 148.22; Purity: ≥95%
4-mercapto-4-methylpentanoic acid
Unit Price(USD)Quantity & Buy
500 mg$460
1 g$578
Bulk inquiry

Inquire about bulk pricing for large orders!

AP10759Phthalimidoxy-PEG1
Quick viewPhthalimidoxy-PEG1
207.18≥95% Pricing
M.W: 207.18; Purity: ≥95%
Phthalimidoxy-PEG1
Unit Price(USD)Quantity & Buy
100 mg$286
250 mg$330
1 g$410
5 g$990
Bulk inquiry

Inquire about bulk pricing for large orders!

AP10140Bocaminooxy-PEG2-BCN
Quick viewBocaminooxy-PEG2-BCN
497.58≥95% Pricing
M.W: 497.58; Purity: ≥95%
Bocaminooxy-PEG2-BCN
Unit Price(USD)Quantity & Buy
100mg$700
250mg$1400
500mg$2100
1g$3150
Bulk inquiry

Inquire about bulk pricing for large orders!

AP123775,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-hydroxy, 9H-fluoren-9-ylmethyl ester
Quick view5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-hydroxy, 9H-fluoren-9-ylmethyl ester
635.75≥95% Pricing
M.W: 635.75; Purity: ≥95%
5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-hydroxy, 9H-fluoren-9-ylmethyl ester
Unit Price(USD)Quantity & Buy
250mg$570
500mg$855
1g$1280
Bulk inquiry

Inquire about bulk pricing for large orders!

AP10760Phthalimidoxy-PEG2
Quick viewPhthalimidoxy-PEG2
251.24≥95% Pricing
M.W: 251.24; Purity: ≥95%
Phthalimidoxy-PEG2
Unit Price(USD)Quantity & Buy
500 mg$330
1 g$580
Bulk inquiry

Inquire about bulk pricing for large orders!

Bulk Inquiry


    close
    Linkers
    • Polyethylene Glycol PEG Linkers
      • Acid PEG
      • Aldehyde PEG
      • Alkyne PEG
      • Amino PEG
      • Aminooxy PEG
      • Azide PEG
      • BCN-PEG
      • Benzyl-PEG
      • Biotin PEG
      • Bis-PEG-acid
      • Bis-PEG-NHS
      • Bis-Sulfone PEG
      • Boc-PEG
      • Branched PEG
      • Bromo PEG
      • Cleavable Linkers
      • DBCO PEG
      • Diketone PEG
      • DNP PEG
      • DOTA Reagent DOTA PEG
      • DSPE PEG
      • Fluorescent PEG
      • Fmoc PEG
      • Folate PEG
      • Homobifunctional PEG
      • Hydrazide PEG
      • Hydroxy PEG
      • HyNic PEG
      • Iodo PEG
      • Lipid PEG
      • M-PEG
      • Maleimide PEG
      • MeNH-PEG
      • NHS ester PEG
      • Non-PEG linker
      • PEG-t-butyl ester
      • PEG-X-PEG
      • Peptide Linkers
      • PFP ester PEG
      • Phosphonate PEG
      • Propargyl PEG
      • PROTAC Linker
      • Silane PEG
      • SPDP PEG
      • Sugar PEG β-Glucuronide Linker
      • Sulfonic acid PEG
      • TCO PEG
      • Tetrazine PEG
      • Thiol PEG
      • Tosylate PEG
    • Polymer PEG
      • Acrylate
      • Active ester
      • Aldehyde
      • Amine
      • Azide
      • Biotin
      • Boc
      • Carboxylic acid
      • Cholesterol
      • DBCO
      • Fmoc
      • Folate
      • guanlian1010
      • Hydrazide
      • Hydroxyl
      • Lipoamide
      • Maleimide
      • MW 2000
      • MW 5000
      • Polysarcosine
      • Silane
      • Stearic acid
      • TCO
      • Thiol
    • Click Chemistry Tools & Reagents
      • Click Chemistry Auxiliary Reagents
      • Methylcyclopropene Linkers
      • PTAD Linker
    • Cleavable Linkers
      • -S-S- Cleavable
      • Cleavable Peptide
      • Dde Cleavable Linkers
      • diazo biotin probes
      • Disulfide Linkers
      • DTSSP crosslinker
      • PC Cleavable
      • Photocleavable Biotin
      • β-Glucuronide Linkers
    • Amine reactive Linkers
    • Acid reactive Linkers
    • Thiol reactive Linkers
    • Carbonyl reactive Linkers
    • Target Specific Linkers
      • APN Linkers
      • Folic Acid PEG Linker
      • Haptens
    Probes
    • Fluorescent Dye
      • AF Dyes
      • APDye Fluors
      • Bodipy Probes
      • Classic Fluorescent Dyes
      • Coumarin 343
      • Cyanine Dyes
      • Fluorescein (FAM)
      • IR Fluors
      • JOE
      • MB Dyes
      • Peptide Labeling Reagents
      • Pyrene Probes
      • Quenchers
      • R6G
      • Rhodamine Dye
      • Rox (carboxy-X-rhodamine) Dye
      • TAMRA Dye
    • Image Probes
      • Diazirine Linkers
      • DOTA PEG
      • Fluorescent PEG
    Modifiers
    • Surface Modifier
      • PEG Phosphonate
      • PEG Silane
      • PEG Sulfonic acid
    • Drug Formulation
      • Lipids for Drug Delivery
    axispharm

    AxisPharm | ADC technologies & Analytical Services. | High Purity PEG Linkers ADC Linkers Supplier.

    5820 Oberlin Drive, Suite 104,San Diego, California 92121, USA

    phone:1-858-677-9432
    fax: 1-858-228-1081
    email: sales@axispharm.com

    Services & Pricing
    • Bioanalytical Service
    • Analytical Services
    • Proteomics Services
    • Formulation Services
    • ADC Conjugation Service
    • General Pricing List
    • PK Study Pricing List
    • GCMS GCFID Pricing
    • Proteomics Service Pricing
    Products
    • ADC Linkers
    • PEG Linkers
    • Click chemistry tools
    • Acid reactive Linkers
    • Amine reactive Linkers
    • Thiol reactive Linkers
    • Carbonyl reactive Linkers
    • Cleavable Linkers
    • Image Probes
    • Fluorescent Dye
    Technical
    • Instrumentation
    • Maldi-TOF Application
    • LCMS
    • GCMS Application
    • Chemistry Services
    • Ion Chromatography – HPIC
    • Titrations
    About us
    • About us
    • Contact us
    • Careers
    • FAQ
    • Blog
    • Privacy Policy
    • News
    • Track Order
    • CAS Number
    • SDS

    2018-2024 ©Copyright AxisPharm

    Facebook Twitter YouTube linkedin
    Axispharm payment method
    • Home
    • Services
      • Service Area
        • Bioanalytical Service – PK Studies
        • Analytical Services
        • Proteomics Services
        • Formulation Services
        • Bioconjugation Service
        • Metabolomics Services
        • Oligonucleotides
        • Custom Synthesis Services
        • In Vitro Diagnostic (IVD) Research and Development
      • Test Type
        • Ion Chromatography – HPIC
        • GCMS Analysis
        • LCMS Analysis
        • LCMSMS Analysis Services
        • Maldi-TOF Analysis
        • Q-TOF-LC-MS and TQ-LC-MS analysis of Oligonucleotides
        • Titrations
      • Analyte Type
        • Small Molecules
        • Protein
        • Oligonucleotides
        • Polymers
      • By Industry
        • Consumer
        • Environmental
        • Forensic
        • Pharmaceutical
    • Products
      • PEG Linkers
      • Lipids for Drug Delivery
      • Fluorescent Dye
      • Click Chemistry Linkers
      • Acid reactive Linkers
      • Amine reactive Linkers
      • Carbonyl reactive Linkers
      • Cleavable Linkers
      • DNA
      • Modifier
      • Polymer PEG
      • Probes
      • Thiol reactive Linkers
      • Payloads and Linker modified Payloads
      • synthetic peptides
    • Instrumentation
      • GCMS1
      • ICP-MS
      • Ion Chromatography – HPIC
      • LCMS
      • Maldi-TOF
      • Orbitrap Mass Spectrometer
      • Q-TOF-LC-MS and TQ-LC-MS
      • Titrations
      • TOF and QTOF Mass Spectrometer
    • Quick Links
      • Sample Preparation Guidelines
      • Online Sample Submission
      • Sample Submission Form (PDF)
      • GCMS GCFID Pricing
      • Analytical Pricing
      • PK Study Pricing
      • Proteomics Cost
      • Metabolomics Services Pricing
    • Blog
    • Contact Us
      • About Us
      • Videos
      • News
      • FAQ
      • Product Support
      • Careers
    • Hello, Sign in

    Shopping cart

    close

    Sign in

    close


    Lost your password?
    No account yet? Create an Account
    Sidebar Scroll To Top
    Facebook Twitter Pinterest linkedin