DSPE-Polysarcosine-Biotin, DP 25 is a biotin-functionalized lipid-polymer conjugate featuring a hydrophobic DSPE lipid anchor and hydrophilic polysarcosine chain. The polysarcosine segment has approximately 25 repeat units, while terminal biotin supports high-affinity avidin and streptavidin binding.
Key Features and Benefits
- Amphiphilic Structure: DSPE-Polysarcosine-Biotin combines a hydrophobic phospholipid anchor with a hydrophilic polysarcosine chain.
- Polysarcosine DP 25: The polymer segment contains approximately 25 sarcosine repeat units, providing a compact hydrophilic spacer.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into lipid membranes and assemblies.
- Biotin Functionality: Terminal biotin provides a high-affinity recognition site specifically for avidin and streptavidin proteins.
- Biotin-Avidin Interaction: Biotin enables strong noncovalent binding with avidin, streptavidin, and related biotin-binding proteins.
- Hydrophilic Polymer Spacer: Polysarcosine separates the DSPE lipid anchor from the terminal biotin functionality.
- Lipid Membrane Incorporation: The DSPE anchor specifically supports incorporation into compatible liposomes, lipid nanoparticles, and lipid assemblies.
- Functional Lipid-Polymer Platform: DSPE, polysarcosine, and biotin provide an especially versatile platform for lipid functionalization and biomaterial research.
Applications
- Biotin-Avidin Binding: DSPE-Polysarcosine-Biotin, DP 25 supports avidin- and streptavidin-based binding systems.
- Bioconjugation: Terminal biotin enables noncovalent attachment to compatible avidin- or streptavidin-functionalized molecules.
- Lipid Nanoparticle Research: Supports incorporation of biotin-functionalized polysarcosine into experimental lipid nanoparticle systems.
- Liposome Research: Enables preparation and functionalization of biotin-containing liposomes and related lipid assemblies.
- Ligand Attachment: Biotin-streptavidin interactions provide a versatile approach for attaching compatible ligands and biomolecules.
- Nanoparticle Functionalization: Supports biotin presentation on compatible lipid-containing nanoparticle systems.
- Surface Modification: Enables presentation of hydrophilic polysarcosine chains and terminal biotin on compatible surfaces.
- Biomaterial Research: Supports development of biotin-functionalized lipid-polymer materials and binding platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Polysarcosine-Biotin, DP 25 combines a DSPE lipid anchor, compact polysarcosine chain, and terminal biotin and specifically supports biotin-avidin binding, lipid functionalization, bioconjugation, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.