DSG-PEG-NH2, MW 2K is an amphiphilic lipid-PEG conjugate containing a terminal primary amine that specifically combines a hydrophobic distearoyl glycerol (DSG) anchor with hydrophilic 2K PEG and amine functionality for conjugation, lipid assembly, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSG-PEG-NH2 combines a hydrophobic DSG lipid anchor with hydrophilic PEG in one functional conjugate.
- PEG MW 2K: The 2K PEG segment provides a hydrophilic spacer between the DSG anchor and terminal amine.
- DSG Lipid Anchor: The distearoyl glycerol moiety specifically supports association with lipid membranes and compatible lipid-based assemblies.
- Primary Amine Functionality: The terminal NH2 group specifically provides a reactive site for coupling and chemical modification.
- Amine-Reactive Coupling: The primary amine can react with activated carboxyl groups, NHS esters, and other compatible electrophiles.
- PEG Spacer: The PEG chain separates the lipid anchor from the terminal amine and provides hydrophilic character.
- Lipid Assembly Capability: The amphiphilic structure specifically supports incorporation into compatible lipid nanoparticles and membrane systems.
- Functional Conjugation Platform: Combines lipid anchoring, PEG spacing, and amine functionality within one material.
Applications
- Bioconjugation: Researchers use DSG-PEG-NH2, MW 2K to attach compatible biomolecules and functional ligands.
- Ligand Conjugation: The terminal amine supports coupling with carboxyl-containing or activated functional molecules.
- Lipid Nanoparticle Research: Supports incorporation into compatible lipid nanoparticle formulations and related lipid assemblies.
- Liposome Research: Enables development and functionalization of PEG-containing liposome systems.
- Nanoparticle Functionalization: Provides an accessible terminal amine for modification of compatible nanoparticle surfaces.
- Polymer Functionalization: Supports coupling of DSG-PEG to compatible polymers and functional materials.
- Surface Modification: Provides a 2K PEG spacer and terminal amine for surface functionalization research.
- Biomaterial Research: Supports development of functional lipid assemblies, conjugates, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged contact with amine-reactive reagents before intended conjugation. Allow the material to reach room temperature before opening to minimize condensation.
DSG-PEG-NH2, MW 2K combines a hydrophobic DSG lipid anchor, hydrophilic PEG spacer, and reactive primary amine and specifically supports bioconjugation, lipid nanoparticle research, ligand attachment, surface modification, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.