(S)-Crizotinib is the S-enantiomer of crizotinib and a small-molecule research compound with biological activity distinct from the clinically used R-enantiomer. Researchers study (S)-Crizotinib specifically for its effects on MTH1 (NUDT1), oxidative DNA damage pathways, and cancer cell biology.
Key Features and Benefits
- Defined S-Enantiomer: (S)-Crizotinib provides the stereochemically defined S-enantiomer of crizotinib for enantiomer-specific research.
- MTH1 Research: (S)-Crizotinib has been studied specifically for inhibition of MTH1, also known as NUDT1.
- Oxidized Nucleotide Research: Supports investigation of cellular mechanisms specifically involving oxidized nucleotides and nucleotide-pool sanitation.
- Oxidative Stress Research: Enables studies specifically examining relationships among oxidative stress, nucleotide damage, and cellular responses.
- DNA Damage Research: Supports investigation of pathways involving damaged nucleotides and genomic integrity.
- Cancer Biology Research: Provides a small-molecule tool specifically for studying MTH1-associated pathways in cancer cell models.
- Stereochemical Research: Enables comparison of biological activities associated with different crizotinib stereoisomers.
Applications
- MTH1/NUDT1 Research: Researchers use (S)-Crizotinib to investigate MTH1 activity and associated cellular pathways.
- Oxidative DNA Damage Research: Supports studies of oxidized nucleotide processing and its relationship to DNA damage.
- Oxidative Stress Studies: Enables investigation of cellular responses to oxidative stress and nucleotide oxidation.
- Cancer Biology Research: Supports studies of MTH1-associated mechanisms in cancer cell models.
- Cellular Response Research: Enables investigation of downstream cellular responses associated with MTH1 inhibition.
- Enantiomer Research: Supports comparative studies examining stereochemistry-dependent activity of crizotinib enantiomers.
- Mechanistic Research: Provides a small-molecule research tool for investigating MTH1-related biochemical and cellular mechanisms.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under appropriate conditions. Protect from moisture and excessive heat.
- Handling: Follow standard laboratory procedures for small-molecule research compounds. Prepare and store solutions according to experimental requirements and stability considerations.
This product provides a stereochemically defined research compound for studying MTH1 and oxidative nucleotide pathways and specifically supports oxidative stress, DNA damage, cancer biology, and enantiomer-specific research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
