DOPE-PEG-SH, MW 3.4K is a thiol-functionalized phospholipid-PEG conjugate containing a hydrophobic DOPE lipid anchor and hydrophilic 3.4K PEG spacer, while its terminal thiol group supports bioconjugation, surface functionalization, lipid nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DOPE-PEG-SH combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 3.4K: The 3.4K PEG spacer provides hydrophilic character and separates the terminal thiol from the lipid anchor.
- DOPE Lipid Anchor: Dioleoyl phosphatidylethanolamine specifically provides two unsaturated lipid chains for incorporation into lipid membranes and assemblies.
- Thiol Functionality: The terminal sulfhydryl group specifically provides a versatile reactive site for conjugation and surface modification.
- Maleimide-Reactive Chemistry: The thiol group reacts with maleimide-functionalized molecules to form stable thioether linkages.
- Metal Surface Affinity: Thiol functionality specifically supports attachment to compatible metal surfaces, including gold-based nanomaterials.
- PEG Spacer: The PEG chain provides spatial separation between the lipid anchor and reactive thiol group.
- Functional Lipid Platform: DOPE, PEG, and thiol functionality provide a versatile platform for lipid and nanomaterial modification.
Applications
- Thiol Conjugation: Researchers use DOPE-PEG-SH, MW 3.4K for reactions with compatible thiol-reactive molecules.
- Bioconjugation: Supports coupling with maleimide-functionalized peptides, proteins, ligands, polymers, and other molecules.
- Lipid Nanoparticle Research: Enables introduction of PEG and thiol functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports functionalization of liposomes and other phospholipid assemblies.
- Nanoparticle Functionalization: The terminal thiol supports modification and conjugation of compatible nanomaterials.
- Gold Nanoparticle Research: Thiol functionality supports anchoring to gold surfaces for nanoparticle and surface research.
- Surface Modification: Provides a thiol-functional PEG linker specifically for compatible material surfaces.
- Biomaterial Research: Supports development of functional lipid-PEG conjugates, nanomaterials, and biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to air to reduce oxidation of thiol groups.
DOPE-PEG-SH, MW 3.4K combines a DOPE lipid anchor, hydrophilic PEG spacer, and reactive terminal thiol and specifically supports bioconjugation, lipid nanoparticle modification, liposome functionalization, nanomaterial conjugation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
