DOPE-PEG-Biotin, MW 3.4K is a biotin-functionalized phospholipid-PEG conjugate containing a hydrophobic DOPE lipid anchor and hydrophilic 3.4K PEG spacer, while its terminal biotin group supports avidin and streptavidin binding, bioconjugation, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DOPE-PEG-Biotin combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 3.4K: The 3.4K PEG spacer provides hydrophilic character and separates the terminal biotin from the lipid anchor.
- DOPE Lipid Anchor: Dioleoyl phosphatidylethanolamine provides two unsaturated lipid chains for incorporation into lipid membranes and assemblies.
- Biotin Functionality: The terminal biotin specifically provides a high-affinity recognition group for avidin and streptavidin systems.
- Biotin-Avidin Interaction: Biotin specifically supports strong noncovalent binding with avidin, streptavidin, and related biotin-binding proteins.
- PEG Spacer: The PEG chain provides spatial separation between the DOPE anchor and terminal biotin group.
- Lipid Assembly Capability: The amphiphilic structure specifically supports incorporation into liposomes, lipid nanoparticles, and related lipid systems.
- Functional Lipid Platform: DOPE, PEG, and biotin functionality specifically provide a versatile platform for lipid and nanomaterial modification.
Applications
- Biotin-Avidin Binding: Researchers use DOPE-PEG-Biotin, MW 3.4K in avidin- and streptavidin-based binding systems.
- Bioconjugation: Supports noncovalent assembly with streptavidin-linked proteins, ligands, probes, and other molecules.
- Lipid Nanoparticle Research: Enables introduction of PEG and biotin functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports biotin functionalization of liposomes and other phospholipid assemblies.
- Ligand Attachment: Biotin-streptavidin interactions provide a versatile approach for attaching compatible ligands to lipid systems.
- Nanoparticle Functionalization: Supports biotin-mediated modification of compatible nanoparticles and nanomaterials.
- Surface Modification: Provides a biotin-functional PEG component for affinity-based surface engineering.
- Biomaterial Research: Supports development of biotinylated lipid-PEG materials and functional biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DOPE-PEG-Biotin, MW 3.4K combines a DOPE lipid anchor, hydrophilic PEG spacer, and terminal biotin functionality and specifically supports avidin-streptavidin binding, bioconjugation, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
