DOPE‑mPEG, MW 5 000 (1,2‑Dioleoyl‑sn‑glycero‑3‑phosphoethanolamine‑N‑methoxypolyethylene glycol, MW 5 000) is an amphiphilic PEGylated phospholipid. It consists of a hydrophobic DOPE lipid tail (with two unsaturated C18 chains) and a long hydrophilic mPEG 5 000 chain.
Key Features
- Amphiphilicity: Self‑assembles into liposomes, micelles, or lipid nanoparticles in aqueous media.
- Stealth effect: The long PEG 5 000 forms a thick hydration layer that reduces protein adsorption, immune recognition, and RES clearance, significantly prolonging in vivo circulation time.
- Membrane fusion: DOPE’s unsaturated structure enables efficient insertion into lipid bilayers and promotes membrane fusion for intracellular delivery.
- Biocompatible: Low immunogenicity and toxicity.
- Purity: Typically ≥ 95% (HPLC)AxisPharm.
- Storage: −20 °C, dry, avoid repeated freeze‑thaw cycles.
Main Applications
- Formulation of long‑circulating stealth liposomes and lipid nanoparticles (LNPs).
- Drug delivery (small molecules, nucleic acids, vaccines) with enhanced stability and bioavailability.
- Surface modification of nanocarriers for targeted therapy.
- Gene delivery and cell membrane engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
