DODAP (18:1) is an ionizable cationic lipid with low cytotoxicity and high transfection efficiency. It appears neutral at physiological pH, but once the pH falls below its pKa (<7), the protonation of the free amine acquires a positive charge in the endosome. A common area of application for DODAP (18:1) is ionizable lipid components in nanomedicine as nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), which are widely used to encapsulate bioactive molecules, including mRNA , siRNA and plasmid DNA to treat disease.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.