Diazo Biotin-PEG3-DBCO
This product is a multifunctional linker containing a diazo group, a biotin moiety, a PEG3 spacer, and a dibenzocyclooctyne (DBCO). It specifically enables photoreactive labeling, streptavidin binding, and copper-free click chemistry, offering solubility and versatile functionality.
Key Features and Benefits
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Diazo Group: Provides photoreactive labeling through light-induced insertion.
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Biotin Moiety: Enables high-affinity streptavidin and avidin binding.
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DBCO Group: Reacts rapidly with azides via SPAAC click chemistry.
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PEG3 Spacer: Improves solubility while maintaining compact length.
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Multifunctional Design: Combines photo-crosslinking, affinity capture, and click chemistry.
Applications
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Bioconjugation: Links biomolecules with azides and enables streptavidin binding.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with dual reactive and affinity handles.
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Photoaffinity Labeling: Captures transient biomolecular interactions upon irradiation.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Protect from light; use anhydrous solvents such as DMF or DMSO.
This product integrates photoreactivity, biotin affinity, and copper-free click chemistry in a PEG3 scaffold, specifically enabling advanced multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
