Dde-Biotin-PEG4-alkyne
This product is a heterobifunctional linker combining a biotin group for avidin/streptavidin binding, an alkyne for click chemistry, and a Dde-protected amine for orthogonal synthesis. The PEG4 spacer improves solubility, flexibility, and spacing, making it especially useful for affinity labeling and multifunctional bioconjugation.
Key Features and Benefits:
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Biotin Group: Provides high-affinity binding to avidin/streptavidin systems.
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Alkyne Group: Enables CuAAC or SPAAC click chemistry with azides.
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Dde-Protected Amine: Allows orthogonal, controlled deprotection strategies.
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PEG4 Spacer: Adds hydrophilicity and reduces steric hindrance.
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High Purity: Ensures reproducibility in conjugation workflows.
Applications:
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Affinity Labeling: Biotinylates proteins, peptides, or probes for capture assays.
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Click Chemistry: Couples biomolecules through alkyne–azide ligation.
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PROTAC Development: Supports multifunctional assembly with biotin handles.
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Probe Design: Builds advanced biotin-tagged probes with click-ready handles.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature Dde deprotection.
This product offers biotin affinity, click-ready functionality, and orthogonal protection, making it an especially versatile reagent for bioconjugation, probe development, and chemical biology.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
