DBCO-propanamide-thiol (CAS: 2252493-06-2) is a versatile bioconjugation reagent featuring a DBCO group for copper-free click chemistry, a propanamide linker, and a reactive thiol group. This structure enables selective coupling with azide-tagged biomolecules and further functionalization through the thiol group.
Key Features:
- Molecular Formula: C₂₁H₂₀N₂O₂S
- Molecular Weight: 364.46 g/mol
- Functional Groups: DBCO and thiol
- Solubility: Soluble in organic solvents
Applications:
- Bioconjugation: Enables copper-free click chemistry with azide-functionalized molecules, supporting the creation of antibody-drug conjugates and targeted therapeutics.
- Surface Functionalization: The thiol group attaches to gold surfaces and other thiol-reactive substrates, useful in biosensors and diagnostics.
- Polymer Crosslinking: Serves as a crosslinker for hydrogels and polymeric materials, enhancing functionality and stability.
Handling and Storage:
- Storage Conditions: Store at -20°C in a dry, light-protected environment.
- Handling Precautions: Use personal protective equipment and ensure proper ventilation.
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