DBCO-PEG4-Val-Cit-PAB-PNP (CAS: 2226472-28-0) is a cleavable linker commonly used in antibody-drug conjugates (ADCs).
Key Features:
- DBCO Group: Allows copper-free click reactions with azides for efficient conjugation.
- PEG4 Spacer: Improves solubility and reduces steric hindrance.
- Val-Cit Dipeptide: Cleavable by cathepsin B, enabling controlled release within target cells.
- PAB Spacer: Supports effective drug release upon cleavage.
- PNP Group: Serves as a leaving group for easy attachment to amine-containing molecules.
Applications:
- Antibody-Drug Conjugates (ADCs): Links antibodies to cytotoxic drugs, allowing targeted drug delivery to cancer cells.
- Bioconjugation: Connects various biomolecules for research and therapeutic applications.
Storage and Handling:
- Storage: Keep at -20°C in a dry, dark place.
- Handling: Use under inert atmosphere conditions to maintain stability.
DBCO-PEG-Val-Cit is widely used in targeted drug delivery, enabling enzyme-triggered release of therapeutic agents within specific cells, particularly in cancer treatments.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
